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Potential for Insulin Resistance Long-term MK-677 use has been associated with elevated fasting glucose and reduced insulin sensitivity in some users, particularly those predisposed to metabolic dysfunction

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Gut dysbiosis ME/CFS patients often have gastrointestinal (GI) symptoms (189) with gut inflammation (190), gut microbiome dysbiosis (57, 191) and changes in the gut microbiome (191, 192)