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Furthermore, supplemental lycopene has shown to decrease MDA, RAGE, and TNF- α levels in the kidneys of male Wistar rats fed a high-fat diet for 6 weeks [129], and similarly, lycopene orally administered at 25 and 50 mg/kg body weight daily for 3 months protected the kidneys of male Wistar rats fed a high-fat diet by inhibiting the expression of nuclear factor kappa-B, interleukin 1 beta, tumour necrosis factor alpha, decreasing oxidative stress, increasing nuclear factor erythroid 2-related factor 2, and stimulating B-cell lymphoma 2, hence shielding the kidney tissue against damages [66]