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Search strategy We comprehensively searched PubMed, Embase, Cochrane Library, Web of Science, and clinical trials registries ( up until April 29, 2024, for randomized controlled trials (RCTs) that compared the efficacy of once-weekly tirzepatide with placebo in adults with T2D or without T2D

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While the magnitude of this effect varies among individuals, even modest increases in metabolic rate can support sustained fat loss over time