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Serious AEs (SAEs) were defined as an AE that, at any dose, resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, resulted in persistent incapacity, or was a congenital anomaly or birth defect

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For example, another competitive ATP antagonist, SP600125, inhibits both pJNK and MKK4, and so might fomepizole

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