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GLT1, GLAST, and EAAT3 clear synaptic and extra-synaptic glutamate, whereas Sxc – mediates the exchange of extracellular cysteine and intracellular glutamate across the cellular plasma membrane [111]

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While protein disulfide exchange with a thiol can be catalyzed by PDI, some proteins contain a microenvironment in which thiolate (−S − ), which is far more reactive than is a thiol in both reaction with H 2 O 2 or disulfide exchange, is formed

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