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This cGMP-mediated increase in cellular antioxidant enzymes warrants further investigation to determine whether it plays a beneficial role in vivo , and whether it is relevant to the actions of receptor-mediated (particulate) guanylyl cyclase-activation pathways ( e.g ., through atrial natriuretic peptide) or soluble guanylyl cyclase (sGC) pathways ( e.g ., stimulated by NO· ) that activate protein kinase G

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However, whey supplementation appeared to reduce the drop in glutathione typically seen after intense exercise