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10.20517/2347-8659.2020.32 Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive neuron loses in memory-related brain structures

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04 Mechanism Under Investigation Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that methylates nicotinamide using S-adenosyl-L-methionine (SAM) as the methyl donor, has been selectively inhibited by 5-Amino-1MQ in laboratory settings