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65 - 78 Pleiotropic effect involving distinctive receptors, VEGF receptor 2 (VEGFR2), growth hormone receptors, distinctive pathways, VEGFR2-AKT-eNOS (endothelial NOS), ERK½, focal adhesion kinase-paxillin, FoxO3a, p-AKT, p-mTOR and p-GSK-3β, distinctive loops, stimulation egr-1 gene and its corepressor gene naB2 , counteraction of the increased pro-inflammatory and pro-cachectic cytokines, 2 , 96 - 101 would likely minimize the inherent lack of full understanding of the mechanisms which may be involved