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Elamipretide is a cell-permeable tetrapeptide that selectively accumulates in mitochondria, binds cardiolipin, stabilizes inner-membrane structure, inhibits excessive ROS production, and preserves ATP synthesis

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Mitochondria in spermatogonia are typically small and spherical, located in the basal structure of the seminiferous epithelium, and have access to the vasculature and interstitial fluid 41 , which supports low oxidative phosphorylation (OXPHOS) activity at this stage