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Moreover, radical-scavenging antioxidants such as Astragenol, Acteoside, and Edaravone have demonstrated neuroprotective effects in NDDs, primarily by neutralizing ROS, promoting GSH synthesis, and maintaining GPX4 activity to alleviate neuronal ferroptosis (Xiao et al., 2025

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The result is an intermittent cytotoxic suppression of erythroid progenitors and cell stress signaling, due to cell cycle arrest and death at S phase (Agrawal et al., 1976