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A group of patients with very severe neuropathies showed impaired CoQ 10 synthesis, indicating the importance of CoQ 10 homeostasis in human health (Asencio et al., In individuals with primary CoQ 10 deficiency, early treatment with high-dose oral CoQ 10 supplementation improves the pathological phenotype, limits the progression of encephalopathy, and helps recover kidney damage (Montini et al., 2008)

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2008 doi: 10.1016/j.biopsych.2008.03.004