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When you swallow a traditional tablet, the enzymes in your stomach and digestive tract begin to dismantle the tripeptide structure almost immediately

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demonstrated that a very significant part of high molecular weight (300 kDa) histidine-rich protein from rat epidermis is rapidly degraded by the epidermal proteinases, leading to the accumulation of a 56 kDa fragment (Kashima et al., 1988)