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It differs from the native 70 residue growth factor in two respects: glutamate at position 3 is replaced by arginine, and a hydrophobic 13 residue extension (MFPAMPLLSLFVN) is fused to the N-terminus

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In total joint arthroplasty, where wound complications and periprosthetic joint infection carry substantial consequences, perioperative risk minimization should remain the priority