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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

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During the process of phospholipid hydroperoxide being reduced to the corresponding phospholipid alcohols, GSH acts as an electron donor, while glutathione disulfide (GSSG) is produced simultaneously ( Figure 1 ) ( In the cytoplasm, GSH is synthesized through the catalytic action of glutamate cysteine ligase (GCL) and glutathione synthetase (GSS) ( C -