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This review examined six randomized clinical trials with 21,065 treated and 20,997 placebo participants, as well as 45 observational studies (768,886 patient cases and 5.5 million controls), where the lead author stated, “hormones work best for the brain when taken in midlife in the presence of menopausal symptoms to support women through the menopause condition, which may represent a window of opportunity” for HRT [174]

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The primary care practice may not recommend IV infusion if you have a health condition that affects fluid balance or nutrient metabolism, like liver or kidney disease