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High IL-6 plasma levels were shown to have a greater likelihood of mortality, morbidity, and disability in the elderly (Puzianowska-Kuznicka et al., 2016)

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The concentration of reactive oxygen species (ROS) in the ileum is modulated by bacterial load and can inhibit bacterial reflux from the distal intestine through inducible NOS and NADPH oxidase 1, resulting in the production of nitric oxide and superoxide radicals 94

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