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for example, while the VITACOG trial demonstrated reduced brain atrophy with B-vitamin supplementation in MCI [96], most studies have follow-up periods of six months or less, and even large trials such as COSMOS-Mind did not assess dementia incidence [97]

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doi: 10.1056/NEJM200011233432103 18 GautamRSinghMGautamSRawatJKSarafSAKaithwasG