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SULFATION – SAFE PATHWAY (SULT enzymes) • 30-35% of acetaminophen in healthy non-pregnant adults • Attaches sulfate groups for safe elimination • Non-toxic pathway • DECREASES 33% during pregnancy (contrary to previous assumptions)[⁶⁰] • Limited capacity—easily saturated with repeated doses • Predominant pathway in fetuses/children (60-70%) but quickly overwhelmed 3