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Applying a pro-remodeling signal during an active remodeling window is the intuitive appeal, and it mirrors the logic behind combining growth-factor or peptide serums with needling in clinical practice

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Similarly, oral administration of either glutathione or other low-molecular-weight thiols (eg, 2-mercaptopropionylglycine or N-acetyl cysteine) to these patients neither substantially raises intracellular glutathione levels nor alters their acid-base balance or excretion of 5-oxoproline (71