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Many people, including governments and scientists, have been concerned about the toxicity of Cd ever since the Itai-itai sickness first appeared in Japan in 1912 (6)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [47].Wang X, Osinska H, Klevitsky R, Gerdes AM, Nieman M, Lorenz J, Hewett T, Robbins J, Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice