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Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

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doi: 10.1016/j.nbd.2013.07.005 [DOI] [PubMed] [Google Scholar] 12.Koros C, Simitsi AM, Papagiannakis N, et al