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observed that exogenous glutamate inhibits cystine uptake through the cystine/glutamate antiporter system, depleting GSH and inducing an increase in ROS levels and intracellular Ca2+ influx, causing a form of programmed cell death in neuronal cells distinct from apoptosis ( The concept of ferroptosis was first proposed by Dixon et al ( As a form of RCD, ferroptosis differs from apoptosis, necrosis, autophagy, and other forms of cell death